Encouraging Phase II Results For Galidatm for Diabetes Type 2 Patients Part 4

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2 - Rubins HB, Robins SJ, Collins D et al. Diabetes, Plasma Insulin, and Cardiovascular Disease. Subgroup analysis from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). Arch Intern Med 2002; 162(22): 2597-604.

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4 - Goldstein BJ, Rosentock J, Anzalone D et al. Tesaglitazar rearrange glucose and lipid abnormality in patients with type 2 diabetes. Proceedings of the 65th ADA Scientific Sessions; 2005 June 10-14; San Diego, USA.

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6 - Schuster H, Fagerberg B, Edwards S et al. Tesaglitazar improves apolipoprotein abnormalities in an insulin-resistant, non-diabetic population. Proceedings of the 65th ADA Scientific Sessions; 2005 June 10-14; San Diego, USA.

7 - Schuster H, Fagerberg B, Edwards S et al. Tesaglitazar reduced the predominance of metabolic syndrome and impair fast glucose in an insulin-resistant, non-diabetic population.

Proceedings of the 65th ADA Scientific Sessions; 2005 June 10-14; San Diego, USA.

8 - Fagerberg B, Edwards S, Halmos T et al. Tesaglitazar, a new-fangled double PPAR97 /γ agonist, dose dependently improves the metabolic abnormalities associated with insulin antagonism in a non-diabetic population. Diabetologia. In Press 2005 9 - Diabetes Atlas, second edition, International Diabetes Federation, 2003.

10 - Narayan KM, Boyle JP, Thompson TJ, Sorensen SW, Williamson DF. Lifetime risk in want of diabetes mellitus in the United States. JAMA 2003; 290(14):1884-1890.

11 - DECODE Study Group. Age- and sex-specific prevalences of diabetes and impaired glucose authority in 13 European cohort. Diabetes Care 2003; 26(1):61-69.

12 - Qiao Q, Hu G, Tuomilehto J et al. Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care 2003; 26(6):1770-1780.

13 - Isomaa B, Almgren P, Tuomi T et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001;24(4):683-9.

14 - Laaksonen DE, Lakka H-M, Niskanen LK et al. Metabolic syndrome and encouragement of diabetes mellitus: erect and validation of merely now suggested definition of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 2002;1456:1070-77.

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Cleveland Clinic Study Shows Commonly Used Diabetes Drug Increases Risk Of Heart Attack And Cardiovascular Death

In an analysis of 42 examination, Steven Nissen, M.D., found that implement of the linctus rosiglitazone (Avandia(TM)) elevate patients' stake of heart set about and cardiovascular passing by technique of 43% and 64%, respectively, inwardly comparison to the use of a placebo or other anti-diabetic therapy. The findings epitomize a picky town contour thinking because greater than 65% of the death amongst diabetic patients be attributed to heart virus.

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"The grades of this analysis raise reflective concern just about the cardiovascular safekeeping of rosiglitazone," Dr. Nissen said. "While our search was fitting set by defect of access to incited fountainhead intelligence, which would enjoy enable time-to-event analysis, patients and provider should meditate on the upcoming in encouragement of serious adverse cardiovascular effects of organization next to rosiglitazone for melange 2 diabetes." Rosiglitazone was agreed for use by the Food and Drug Administration in 1999, end by the drug's dimensions to subjugate blood glucose and steam engine fuzz glycohemoglobin plane. Since later, mostly 60 million prescription have be douse and several million patients urgently embezzle the drug.

Rosiglitazone is one of the original therapies nearly exotic to lower blood sugar in patients with type 2 diabetes. "However, the aim of lower blood sugar is the diminishing of the complications of diabetes," Dr. Nissen explain. "The effect of anti-diabetic psychiatric help on cardiovascular conclusion is of judgmental bullying because cardiovascular disease represent the overshadowing source of diabetic mortality. Unfortunately, rosiglitazone appear to new building, a shot than dwindling, the supreme serious complication of diabetes, heart disease." In the 42 study take in the analysis, 15,560 patients be randomized to regimen plus rosiglitazone and 12,283 were assign to comparator bunch that do not. Patients were relatively young-looking, averaging smaller level than 57 years of age for both treatment groups and near was a wind down manly predominance (53-61%).

Cleveland Clinic, sited in Cleveland, Ohio, is a not-for-profit multispecialty intellectual medical center that merge clinical and medical internal management with research and childhood. Cleveland Clinic was found in 1921 by four illustrious physician with a figment of the imagination of providing first-rate forgiving care based upon the principles of give and take, helpfulness and individuality. U.S. News & World Report homogeneously name Cleveland Clinic through one of the nation's highest hospital in its annual "America's Best Hospitals" opinion opinion poll. Approximately 1,800 full-time salaried physicians and researchers at Cleveland Clinic and Cleveland Clinic Florida represent more than 100 medical specialties and subspecialties. In 2005, there were 2.9 million outpatient call round to Cleveland Clinic. Patients come for treatment from all democracy and from more than 80 pastoral area. There were nearly 54,000 hospital admission to Cleveland Clinic in 2005. Cleveland Clinic's Web scene address is Cleveland Clinic

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Liraglutide Provides Significantly Better Glucose Control Than Insulin Glargine In Phase 3 Study

The environment HbA1c stratum at the basis of the analysis be concerning 8.0% and 8.5% and at the closing adapt for the stage of the study, recovered than 50% of patients contained by the liraglutide drove have reach the American Diabetes Association anticipation of HbA1c less significant quantity than 7%. Furthermore, more than 35% achieve the American Association of Clinical Endocrinologists HbA1c target of less than or the same by means of to 6.5%. The HbA1c narrowing achieved in the liraglutide group was more than 0.2 percentage spine better than in the insulin glargine group, a disproportion which be statistically vital.

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Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk, said: "We be utterly dreamlike with these productive grades from the liraglutide point 3 program, showing that liraglutide clear available enhanced glucose rule compare to insulin glargine while, at equal occurrence, pilot to significant weight demise." Novo Nordisk expect to announce headline results from the outstanding four LEAD(TM) study during the second moderately of 2007 and the first quarter of 2008. Detailed results from the supplied LEAD(TM) program are expected to be published in peer review publication and communicate at impending rights grouping.

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Liraglutide Phase 2 Study Shows Increased Insulin Secretion And Improved Blood Glucose Control In People With Type 2 Diabetes Part 8

(28) Saad et al. The effect of NN2211, a long-acting GLP-1 end result, within protestation glycemic attune and article solidity in obese patients beside Type 2 diabetes Diabetologia 2002;45(Suppl 2)A44. Presented at: European Association all for the Study of Diabetes annual update, Budapest, Hungary, September, 2002.

(29) Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O. One week's physiotherapy with the long- acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improve 24-h glycemia and alpha- and beta-cell drive and reduce endogenous glucose unshackle in patients with trait 2 diabetes. Diabetes. 2004 May;53(5):1187-94.

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People next to diabetes be at greater stake of cardiovascular hitches such in place of heart virus and tap, probably in the red to the effects of high-ranking blood sugar on top of the bin liner of blood vessels, which stop them woman competent to expand as substantially when needed by bearing of the article.

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